Imipramine
In stock
75mg · 50mg · 25mg
from A$51.20
In brief
Imipramine is a tricyclic antidepressant. Its Australian brand, Tofranil, is used to treat major depression and night-time bed-wetting in children aged 5 or older whose bed-wetting has no physical cause.
Imipramine (Tofranil) overview
Two uses appear in the healthdirect entry for Tofranil: major depression, and bed-wetting at night in children from 5 years old once a physical cause has been excluded. Imipramine, the ingredient, belongs to the tricyclic antidepressants.
This listing shows imipramine 25 mg, 50 mg and 75 mg. It does not name the manufacturer of the tablets supplied, so check the label on the pack you receive and confirm with your prescriber or pharmacist that it matches your prescription.
Registered strengths compared with this listing
Tofranil reaches Australian pharmacies through Amdipharm Mercury (Australia) as sugar-coated 10 mg and 25 mg tablets. It is a Prescription Only (Schedule 4) medicine with a PBS subsidy. Neither 50 mg nor 75 mg is a Tofranil strength in the healthdirect listing.
Imipramine 50 mg: price by pack
Compare packs of the same strength. These examples are for 50 mg and are calculated from the listed prices at the shop’s Australian-dollar rate on 8 October 2026, before delivery or other checkout charges.
| Strength | Pack size | Pack price | Price per tablet |
|---|---|---|---|
| 50 mg | 30 | A$77.56 | A$2.59 |
| 50 mg | 60 | A$117.21 | A$1.95 |
| 50 mg | 90 | A$162.03 | A$1.80 |
Relative to the 30 pack, a tablet costs about 24.4% less in the 60 pack and about 30.4% less in the 90 pack.
A lower price per tablet means a larger upfront payment. Choose only the quantity and strength appropriate to your prescription, and check the expiry date. Prices can change, so confirm the current pack price before ordering.
Expect a gradual response
Real benefit may not be felt for 4 to 6 weeks, the Tofranil consumer medicine information explains. It also says not to stop without consulting your doctor.
Tofranil contraindications
In the Tofranil consumer information, it is ruled out after a recent heart attack while recovery is under way, and for anyone allergic to imipramine or a related tricyclic. MAO inhibitors cannot be taken at the same time; a two-week gap is needed after the last dose of one.
Mood changes and other precautions
Thoughts of suicide are a recognised risk, more so in young people, and the consumer information asks for the doctor to be contacted straight away if they arise.
The same document asks for caution with seizures, glaucoma, heart disease or difficulty passing urine, advises avoiding alcohol, and says to wait before driving until the person knows how the medicine affects them. According to healthdirect, over-65s taking Tofranil face particular risks to talk through with a doctor, and pregnancy calls for advice from a doctor or pharmacist.
Side effects reported with Tofranil
Frequently reported: constipation, dry mouth, blurred vision, drowsiness, dizziness, weight gain and sexual dysfunction.
Serious: allergic reactions, uncontrolled movements, severe confusion and an irregular heartbeat.
Interacting medicines and products
Warfarin, SSRIs, MAO inhibitors, anticonvulsants, blood pressure medicines, some cold preparations and nicotine products all appear in the consumer information as interacting with Tofranil.
Storage conditions
For Tofranil, healthdirect specifies a temperature under 30 °C and protection from moisture. Follow the storage directions on the pack you receive.
Frequently asked questions
Which drug class does imipramine belong to?
Tricyclic antidepressants.
Why is a 50 mg strength listed when Tofranil comes as 10 mg and 25 mg?
The 50 mg and 75 mg tablets on this page are not Tofranil strengths registered in Australia.
Delivery across Australia
Airmail service: delivery in 14–22 days, free on orders over A$286.52. Trackable service: delivery in 7–14 days, with the tracking number sent by email. These are estimated delivery times, not guaranteed arrival dates.
Australian cities and delivery information
The Australian delivery options above apply to the destinations below. A city listing does not indicate a physical pharmacy branch or local stock.
| City | State or territory |
|---|---|
| Sydney | New South Wales |
| Melbourne | Victoria |
| Brisbane | Queensland |
| Perth | Western Australia |
| Adelaide | South Australia |
| Hobart | Tasmania |
| Gold Coast | Queensland |
| Canberra | Australian Capital Territory |
| Cairns | Queensland |
| Central Coast | New South Wales |
| Townsville | Queensland |
| Darwin | Northern Territory |
| Newcastle | New South Wales |
| Geelong | Victoria |
| Gladstone | Queensland |
| Port Macquarie | New South Wales |
| Bathurst | New South Wales |
| Forbes | New South Wales |
| Geraldton | Western Australia |
| Goulburn | New South Wales |
